Antimicrobial activity of wild plant seed extracts against human. Screening of hepatoprotective activity of medicinal plant. The aim of present study was to investigate hepatoprotective activity of ethanolic extract of whole plant of hibiscus platanifolius linn in rifampicin induced hepatotoxicity in wistar albino rats in which hepatotoxicity was induced by rifampicin mgkg, b. The present study was done to evaluate the hepatoprotective and the in vivo antioxidant activity of ethanolic extracts of leaves of the plant in carbon tetrachlorideinduced liver damage in rats. Hepatoprotective activity of the ethanolic extract of ficus. In addition, different extracts of the plant were examined for their hepatoprotective activity against cc1 4induced hepatotoxicity in albino rats. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. Hepatoprotective activity of methanolic extract of rhyncosia. The present study was carried out to screen and evaluate the hepatoprotective activity of leaf extracts of aegle marmelos l. Histopathologic examination assured the hepatoprotective activity of the extracts.
The plant phenolic compounds such as flavonoids and isoflavons have an important role in the treatment of many diseases and some of them induce a potent antioxidant and hepatoprotective effect. Evaluation of hepatoprotective activity of adansonia digitata. Evaluation of hepatoprotective activity of alcoholic, chloroform and aqueous extracts of convolvulus pluricalis choisy author. Hepatoprotective activity of methanolic extract of. The present investigation is aimed to evaluate the hepatoprotective effects of citrus hystrix and citrus maxima red and white variety methanolic leaf extracts on paracetamol induced toxicity. This work and the related pdf file are licensed under a creative commons. The hepatoprotective effect of the methanolic extract of adansonia digitata l. Different medicinal herbs and plants extracts have potent hepatoprotective activity in various animal models. In india, more than 87 plants are used in 33 patented and proprietary multi ingredient plant formulations. Keeping this view in the mind, bark extracts of terminalia catappa was selected for to evaluate the hepatoprotective activity. The petroleum ether and hydro alcoholic extracts of pterospermum acerifolium belonging to the sterculiaceae family were studied for hepatoprotective activity against albino rats with liver damage induced by paracetamol. Alchornea cordifolia is a medicinal plant, whose ethanolic and methanolic extracts have shown antioxidant activity which could confer hepatoprotective effect, knowing that liver cells are attacked by free radicals. Hepatoprotective activity of the ethanolic extract of ficus caricalinn. In view of this a study carried out to identify the hepatoprotective activity of plant parts leaf, bark, collar, flower and hypocotyls of ceriops decandra.
Evaluation of hepatoprotective activity of ethanolic. The hepatoprotective effect of the extract of the stem of the plant 200600 mgkg was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase alt, aspartate aminotransaminase ast, and alkaline phosphatase activities alp, antioxidant enzymes like superoxide dismutase sod, catalase cat, and glutathione peroxidase gpx, reduced glutathione gsh and histopathological study of the. Pdf hepatoprotective activity of methanolic extract of. Medicinal plants with hepatoprotective activity in iranian. Among the medicinal plants, myrtus communis family myrtaceae known as myrtle is a useful indian medicinal plant which has. A recent update on hepatoprotective potential of herbal plant. Hepatoprotective and antioxidant activity of methanol extract. Antioxidant activity and hepatoprotective effect of an.
Leaf extracts were given in the dose of 200 mgkg body weight for 7 days and toxicity was induced by paracetamol 2 gkg on day 5. The aqueous extracts afew2 of fresh whole plant of anoectochilus formosanus family of orchidaceae at dose mgkg showed inhibition of chronic hepatitis induced by ccl4 in mice by reducing sgpt and hepatic hydroxyproline level. International journal of green pharmacy,july 2010, 220223. The methanolic extracts, comparable to silymarin as a conventional drug, exhibited a higher hepatoprotective activity. In the in vivo studies, the ccl4 treated control rats showed a significant alteration in the levels of. The present study was carried out to evaluate ficus glomerata extracts for antioxidant and hepatoprotective properties. Research article open access evaluation of hepatoprotective activity of eriocaulon quinquangulare in vitro using. Hepatoprotective activity of some medicinal plants in sudan ncbi. The chicory has several properties including that of lower blood sugar, lipids, reduce uric acid and also has hepatoprotective activity. Antioxidant and hepatoprotective activity of pimenta. The use of plant extracts in therapy dates back many years. Plant extracts have been commonly used over the years for the treatment and prevention of chronic and acute diseases, and health promotion. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim abstract the aim of the study is to investigate the hepatoprotective activity of melia azedarach leaves extracts against simvastatin induced hepatotoxicity. The genus amaranthus has potential activity as a hepatoprotective agent.
There are many plants and traditional formulations available to treat the liver diseases 5, 6. Hepatoprotective effect of aqueous extracts of some medicinal. In the in vivo studies, the ccl4 treated control rats showed a significant alteration in the levels of antioxidant and hepatoprotective. Pcmintoxication model is a universally established model to study the potential hepatoprotective activity of extracts. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim.
Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. Hepatoprotective activity of methanol extract of some. About 600 commercial herbal formulations with hepatoprotective activity. Pdf hepatoprotective activity of some plants extract against.
Determination of phytoconstituents of nhexane extract of. The ethanolic extract of ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic albino rats induced via carbon tetrachloride. Hepatoprotective effect of three herbal extracts on. Further isolation of the active principles responsible for its hepatoprotective activity is currently in progress within our laboratory. In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. Investigations on hepatoprotective activity of leaf. Hepatoprotective effect of aqueous extracts of some. Hepatoprotective activity of some medicinal plants in sudan hindawi. The effect of chloroform fraction and methanol extracts of stem of calycopteris floribunda on ccl4 induced liver damage in rats with reference to biochemical. Despite one report from philippines detailing the use of l. Pdf hepatoprotective activity of some plants extract. Hepatoprotective effect of leaf extracts from citrus hystrix. Antioxidant and hepatoprotective activities of ethanolic.
Malvaceae was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. Hepatoprotective activities of ethanolic and aqueous extracts of a. Pdf medicinal plants possessed hepatoprotective activity. Hepatoprotective activity of the ethanolic extract of. Radical scavenging activities of lagerstroemia speciosa l. Hepatoprotective and antioxidant activities of amaranthus. A number of studies have shown that the plant extracts having antioxidant activity protect against ccl 4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity 45, 42, 21, 24,46 and38. Evaluation of hepatoprotective activity of amoora rohituka. Introduction the activities carried out by the liver in the body are numerous and include the storage of glycogen gly1, the synthesis of plasma proteins including albumin and coagulation factors, the production of bile, detoxification of toxins, slag and other harmful elements introduced into the body with food or because of environmental pollution and is essential. A detailed study was performed on the antioxidant activity of the. Hepatoprotective and antioxidant activities of amaranthus viridis linn. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Several spectroscopic methods, including gcms, were used to characterize phytochemicals present in the petal extract of l.
In the present study, the methanolic extract of rhyncosia. Meav was screened for hepatoprotective activity in pcm 3 gkg induced hepatotoxicity in wistar rats for 15 days at. Use of plant derived drugs in medical practice has shown that they are relatively nontoxic, safe and free from serious side effects 6. These are traditionally treated by medicinal plants especially in rural areas where they are. The hepatoprotective effect of these extracts has been demonstrated in models of hepatotoxicity. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. Two solutions a and b from plant extract were prepared. Antioxidant and hepatoprotective activities of ethanolic extracts of leaves of premna esculenta roxb. Nayak, y and abhilash, d and vijayanarayana, k and fernandes, j 2008 antioxidant and hepatoprotective activity of pimenta dioica leaves extract. Its hepatoprotective activity is attributed to its antioxidant properties. The goal of the present study was to examine the antioxidant and hepatoprotective activity of some medicinal. Hepatoprotective activity of some indigenous plants. The biological and hepatoprotective activity of plant extracts defends. Hepatoprotective activity reported on following plant.
In conclusion, it is observed that hydroalcoholic extract of aerial parts of c. Hepatoprotective activity of ceriops decandra griff. A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. The effect was dependent on the concentration of plant extracts. Evaluation of hepatoprotective activity of alcoholic. A number of natural tablets show promising hepatoprotective activities in acute and chronic liver damage. The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of pulicaria. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4. Sapindaceae ethanol and aqueous fruit extracts of s. Evaluation of hepatoprotective activity of ethanolic extract.
The ld50 and in vivo hepatoprotective activity carried out with the leaf extract the most potent. Hepatoprotective potential of fumaria indica pugsley whole plant extracts, fractions and an isolated alkaloid protopine, phytomedicine 15 2008 470477. In this study, it was reported that the methanolic extracts of the root of uvaria afzelii, at doses of 125 mgkg, 250 mgkg and 500 mgkg, significantly reduced the serum hepatic enzymes, total and unconjugated bilirubin. Hepatoprotective activity, aerial part, callicarpa macrophylla, antiinflammatory activity. The natives of kerala andmangalore use allspice leaves as medicine for pain, arthritis, fever and stress. This hepatotoxic activity can be measured using sgot, sgpt and mda. Although many plant extracts have been studied, many others have not, therefore, a special issue on the pharmacology of plant extracts is timely. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr.
Evidencebased complementary and alternative medicine. Hepatoprotective and antioxidant activity of methanol. The petroleum ether extract at 50 mgkg was having best activity as it decreased. The parameters studied were serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The aim of the present study is to evaluate the in vitro antioxidant and in vivo hepatoprotective activity of e. The degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase sgot, serum glutamate pyruvate transaminase sgpt,totalprotein tp, totalalbumin ta, alkaline. The hepatoprotective activity of this plant was evaluatedin the experimental acute hepatic damage induced by ccl4 in rat 76. Antioxidant and hepatoprotective activity of garlic chives. Hepatoprotective activity of the extract of homalium letestui stem. Antioxidant and hepatoprotective activity of pimenta dioica. The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of amaranthus tricolor linn. Hepg2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 gml of cpre compared to ccl 4 exposed hepg2 cells.
In vitro and in vivo hepatoprotective activity of cissampelos. Hepatoprotective activity of aqueous seed extract of nigella sativa against highly active antiretroviral therapy induced hepatotoxicity in rats kissi mudie1, daniel seifu2, feyissa challa1, abiy abebe1, asfaw debella1, atsbeha gebregzabher1 1ethiopian public health institute ephi, addis ababa, ethiopia. The methanol extracts of plant materials of some plants like casuarina equisetifolia, cajanus cajan, glycosmis pentaphylla, bixa orellana, argemone mexicana, physalis minima, caesalpinia bonduc, belonging to the different family were studied for hepatoprotective activity against swiss albino rats with liver damage. Hepatoprotective effect of three herbal extracts on aflatoxin b i intoxicated rat liver shyamal s. After complete drying, it was powdered in a multi mill grinder and passed through a 60 mesh sieve. In vitro antioxidant activity and hepatoprotective. African natural products with potential antioxidants and. The berries of pimenta dioica lmerril familymyrtaceae are commonly known as allspice in culinary. Hepatic diseases liver diseases are a major worldwide health problem, with high endemicity in developing countries. With a view that sterols, flavonoids, furanocoumrains and triterpens found in medicinal plants are used as hepatoprotective drugs 11, it was thought worthwhile to. Preparation of plant extracts the roots were collected, washed and dried at room temperature. Sgpt, sgot, alp bilirubin and total protein were measured.
Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Review on some medicinal plants with hepatoprotective activities. Evaluation of hepatoprotective activity of adansonia. Hepatoprotective activity of the extract of homalium. In all these pathological conditions oxidative stress is one of the causes, hence we tried extract the leaves for in vitro antioxidant activity. Current study demonstrated potential hepatoprotective activity of nhexane extract of. In india, numerous medicinal plants are used for the treatment of liver disorders. Hepatoprotective activity of aerial parts of plant extract. Abstractelaeis guineensis, a medicinal herb, is commonly used in folk medicine to treat various diseases. In our research, we decided to demonstrate that peptides isolated from anethum graveolens l. Investigations on hepatoprotective activity of leaf extracts. The methanol extract of the fruit pulp of adansonia digitata l. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world. To study heaptoprotective activity of methanolic extract of whole plant of amaranthus viridis linn meav in paracetamol pcm induced hepatotoxicity.
In addition, hepatospecific serum markers will be disturbed. Antimicrobial activity of wild plant seed extracts against. Hepatoprotective activity of methanolic extract of rhyncosia beddomei baker leaves against shanaz banu abstract rhyncosia beddomei baker commonly known as adavikandi, vendiaku in telugu belongs to the family fabaceae. The results of this study indicate that extracts of leaves and plants extracts of some medicinal plant have good potentials for use in. Antioxidant and hepatoprotective effects of croton. The hepatoprotective activity is probably due to the presence of flavonoids, phenolic compounds, polyphenols etc in all few herbal plants. Nearly 160 phytoconstituents from 101 plants have been claimed to possess liver protecting activity. Test extracts were made with the traditional medicinal plants refluxed in 95% meoh and orally administered to the rats.
Hepatoprotective activity of the medicinal plants name of plant source or family plant parts used hepatotoxic inducing agents extracts studied biochemical and histopathological parameters studied boerhaavia diffusa. Hepatoprotective activity of aerial parts of plant extract of. Hepatoprotective activity of dried and fermentedprocessed virgin coconut oil, evidencebased complementary and alternative medicine, vol. Hepatoprotective activity of extracts from stem of. Invivo hepatoprotective activity of methanolic extracts of. It was concluded that the hepatoprotective effects of the three plant extracts observed in this study might results from their potent antioxidative properties 5, 6, 7. The purpose of this study was to find the effect of 36 traditional medicinal plant species on hepatoprotective activity screening. It has been reported that 160 phyto constituents from 101 plants have hepato protective activity. Hepatoprotective activity of aqueous and ethanolic bixa orellana l. Apr 23, 2008 the present study was carried out to evaluate ficus glomerata extracts for antioxidant and hepatoprotective properties. Research article open access evaluation of hepatoprotective. Review on some medicinal plants with hepatoprotective. It is established that therapy with chicory extracts leads to normalization of.
In early study we have shown that peptides obtained from 7 plantain plantago major l. Hepatoprotective effect of leaf extracts from citrus. Aqueous and alcoholic extracts of terminalia catappa were taken. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar. In vitro antioxidant study carried out with dpph, hrsa, no, frap and lpo assays.
Hepatoprotective activity of methanolic extract of bauhinia. The aim of this study was to screen various solvent extracts of whole plant of torilis leptophylla to display potent antioxidant activity in vitro and in vivo, total phenolic and flavonoid contents in order to find possible sources for future novel antioxidants in food and pharmaceutical formulations. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. Hepatoprotective activity of melia azedarach leaf extract against simvastatin induced hepatotoxicity a. Antioxidant activity, total phenolic and total flavonoid. The hepatoprotective effect of the extract of the stem of the plant 200600 mgkg was evaluated by the assay of liver function parameters, namely total and.
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